Mesotherapy for Face, Under-Eye Area and Skin Rejuvenation in Turkey

Mesotherapy is a broad term used for treatments in which small amounts of biologically active substances are delivered into or immediately beneath the skin through multiple fine injections.

In aesthetic medicine, mesotherapy does not refer to one single product. Different formulations may contain hyaluronic acid, amino acids, polynucleotides and other skin-supporting ingredients, depending on the treatment area and clinical objective.

At Anka Plastic Surgery, we do not use one standard mesotherapy formula for every patient.

The product is selected according to the patient’s skin quality, age-related changes, under-eye anatomy, fine lines, hydration and treatment goals.

Our usual initial protocol consists of three sessions approximately two weeks apart, followed by maintenance treatment every 6 to 12 months when appropriate.

What Is Mesotherapy?

Mesotherapy involves placing small quantities of selected ingredients into the skin through multiple microinjections.

The objective depends entirely on what is being injected.

Some formulations are designed primarily to support:

• skin hydration,
• elasticity,
• fine lines,
• dermal quality,
• and a dull or tired skin appearance.

Others contain polynucleotides intended to support regenerative tissue processes.

There are also formulations designed specifically for anatomically sensitive regions such as the under-eye area.

For this reason, the question “What does mesotherapy do?” cannot be answered without knowing which product and which biological ingredients are being used.

What Is Facial Mesotherapy?

Facial mesotherapy is used primarily to support skin quality rather than create significant facial volume.

It may be considered for patients with:

• early fine lines,
• reduced skin hydration,
• dull skin,
• mild loss of elasticity,
• or age-related deterioration in skin texture.

The intention is generally to improve the condition of the skin itself.

This is different from using dermal filler to build the cheeks, project the chin or increase lip volume.

Is Mesotherapy the Same as Dermal Filler?

No.

Although both involve injections, they have different objectives.

Dermal fillers are generally used to create structural volume or contour.

Mesotherapy uses smaller quantities of product, usually in more superficial tissue planes, with the primary aim of supporting skin quality.

Even when both contain hyaluronic acid, the formulation, physical characteristics and purpose of the product can be very different.

Hyaluronic Acid and Amino Acid Mesotherapy

Some skin rejuvenation formulations combine hyaluronic acid with specific amino acids.

Amino acids are the building blocks used by the body to produce proteins, including structural components of the dermal extracellular matrix.

Hyaluronic acid, meanwhile, has a high capacity to bind water and is widely used to support skin hydration.

In our clinical practice, Jalupro is one of the products we use within this category.

What Is Amino Acid Mesotherapy Used For?

Amino acid and hyaluronic acid formulations can be considered when the main concern is:

• reduced skin quality,
• fine lines,
• mild loss of elasticity,
• dryness,
• or a tired and less luminous appearance.

The aim is not to dramatically change facial shape.

Instead, treatment is directed towards the dermal environment and overall skin quality.

What Does Hyaluronic Acid Do in Mesotherapy?

Hyaluronic acid naturally occurs in human tissues and has an important role in hydration.

The hyaluronic acid used in mesotherapy is not necessarily the same highly cross-linked material used in volumising dermal fillers.

In skin-quality treatments, it is generally used for its ability to support:

• hydration,
• elasticity,
• and the appearance of smoother skin.

This is why a hyaluronic acid mesotherapy treatment should not automatically be described as facial filler.

Under-Eye Mesotherapy

The under-eye area has exceptionally thin skin and a distinctive anatomy.

For this reason, product selection is particularly important.

We do not use ordinary facial mesotherapy products indiscriminately beneath the eyes.

In selected patients, we use an under-eye formulation such as Redensity II, depending on the anatomy and the nature of the concern.

What Can Under-Eye Mesotherapy Treat?

Under-eye treatment may be considered for selected patients with:

• mild hollowness,
• a tired appearance,
• fine lines,
• reduced skin quality,
• or an uneven transition between the lower eyelid and cheek.

The purpose is to produce a subtle improvement rather than create obvious volume.

Does Under-Eye Mesotherapy Remove Eye Bags?

No.

This distinction is important.

True under-eye bags usually result from structural prominence of the lower eyelid fat pads.

Mesotherapy cannot remove these fat compartments.

If a patient has significant lower eyelid bags, excess skin or lower eyelid laxity, lower blepharoplasty may be more appropriate.

Trying to treat every under-eye problem with injections can produce unnecessary swelling without correcting the underlying anatomy.

Can Under-Eye Treatment Cause Swelling?

Yes.

The under-eye region is particularly prone to fluid retention because of its thin tissues and lymphatic anatomy.

This is why both patient selection and conservative product volume are important.

Patients with significant pre-existing oedema or malar bags may not be good candidates for certain injectable treatments.

Polynucleotide and “Salmon DNA” Treatments

The term “salmon DNA treatment” is widely used in aesthetic medicine.

More precisely, these treatments usually involve polynucleotides, which are chains of nucleotides derived from purified DNA material.

They are different from hyaluronic acid fillers and are primarily used as regenerative skin-quality treatments.

In our practice, Rejuran is one of the polynucleotide products we use.

What Are Polynucleotides?

Polynucleotides are long chains composed of nucleotide units.

In aesthetic medicine, they are used with the intention of supporting the skin’s regenerative environment rather than simply adding volume.

Research has explored their potential effects on fibroblast activity, extracellular matrix organisation and tissue repair.

For patients, the simplest distinction is that polynucleotides are skin-regenerative injectables rather than conventional volumising fillers.

What Is Salmon DNA Mesotherapy Used For?

Polynucleotide treatments may be considered for:

• fine lines,
• declining skin quality,
• mild loss of elasticity,
• thin or stressed-looking skin,
• and general regenerative skin support.

They do not produce the immediate projection associated with lip or cheek filler.

The change is usually more subtle and directed towards skin quality rather than facial shape.

Do Polynucleotides Stimulate Collagen?

Experimental and early clinical research suggests that polynucleotides may influence fibroblast and extracellular matrix activity.

However, it is more accurate to say that these treatments are intended to support regenerative and remodelling processes rather than guarantee a predetermined amount of new collagen formation.

Skin biology is complex, and individual responses vary.

Are Polynucleotides the Same as Hyaluronic Acid?

No.

They are different biological molecules.

Hyaluronic acid is particularly important for water binding and hydration.

Polynucleotides are used primarily for their potential effects on cellular and tissue-regenerative processes.

Some injectable formulations may combine different ingredient groups, but their biological functions should not be treated as identical.

Mesotherapy for Submental Fat

Mesotherapy can also be used for a completely different purpose in selected patients with a small, localised pocket of fat beneath the chin.

This is not the same treatment as facial skin rejuvenation.

For limited submental fat, we may use phosphatidylcholine-based injection protocols in carefully selected patients.

What Is Phosphatidylcholine Mesotherapy for the Double Chin?

Phosphatidylcholine has been used in injectable lipolysis protocols designed to reduce small areas of localised subcutaneous fat.

In the submental region, treatment may be considered when the patient has:

• a relatively small pocket of fat,
• reasonable skin elasticity,
• no major skin excess,
• and a preference for a non-surgical treatment.

The injections are placed in controlled amounts into the fatty layer.

The objective is limited contour improvement, not large-volume fat removal.

Who Is Suitable for Double-Chin Mesotherapy?

The best candidates generally have mild to moderate localised submental fat and relatively good skin quality.

It is much less suitable when the apparent “double chin” is primarily caused by:

• loose skin,
• weak chin projection,
• platysmal bands,
• significant fat volume,
• or deeper neck anatomy.

In these situations, chin filler, submental liposuction, neck lifting or another procedure may address the actual problem more effectively.

What Happens After Phosphatidylcholine Treatment?

Temporary swelling can be relatively noticeable after treatment.

Patients may also experience:

• tenderness,
• redness,
• bruising,
• or a temporary burning sensation.

The immediate appearance should therefore not be interpreted as the final contour.

Several treatments may be required depending on the amount of fat and the individual response.

Which Areas Can Be Treated With Mesotherapy?

The treatment area depends on the product.

Skin-quality mesotherapy is most commonly used on the:

• face,
• under-eye region,
• neck,
• and décolletage.

Submental phosphatidylcholine treatment is a different protocol directed towards localised fat rather than skin hydration.

Different areas require different products, depths and injection techniques.

For this reason, we do not use a single “whole-face mesotherapy cocktail” for every indication.

Mesotherapy for the Neck

The neck has relatively thin skin and horizontal lines can become noticeable even in younger patients.

Selected mesotherapy formulations may be used to support hydration, fine lines and overall skin quality.

However, mesotherapy cannot physically lift substantial loose neck skin.

Patients with significant laxity require a different treatment strategy.

Mesotherapy for the Décolletage

The décolletage is frequently affected by sun exposure, dryness and progressive skin thinning.

In selected patients, mesotherapy may support skin hydration and texture as part of a broader skin-care programme.

How Is Mesotherapy Performed?

The skin and treatment area are first assessed and the appropriate formulation selected.

The product is then delivered through multiple fine injections.

Injection depth depends on both the product and the anatomy.

Some skin-quality formulations are placed relatively superficially, while the under-eye region requires its own technique.

Treatment is generally relatively short.

A topical anaesthetic cream may be used when appropriate.

How Many Mesotherapy Sessions Do We Recommend?

Our usual starting protocol is three sessions approximately two weeks apart.

After the initial three treatments, the skin response is reassessed.

Maintenance varies according to:

• patient age,
• skin quality,
• product used,
• lifestyle,
• and the degree of improvement.

For many patients, a maintenance session approximately every 6 or 12 months may be appropriate.

Treatment does not need to continue indefinitely on a rigid calendar.

Why Are the First Three Sessions Two Weeks Apart?

Most skin-biostimulation treatments are not designed to create dramatic volume after a single injection.

The initial series provides repeated treatment over a relatively short period.

Following completion of the initial course, the interval can be considerably longer.

Our preference is therefore to use an initial treatment phase followed by individualised maintenance, rather than frequent injections throughout the year.

When Will I See the Results of Mesotherapy?

The timing depends on both the formulation and the skin.

Some patients notice improved hydration and skin appearance relatively early.

Changes related to longer-term tissue remodelling develop more gradually.

For this reason, mesotherapy should not be presented as a one-session facial transformation.

It is primarily a skin-quality treatment.

How Long Does Mesotherapy Last?

Mesotherapy is not permanent.

The skin continues to age and injected biological materials are gradually metabolised.

Maintenance treatments can therefore be considered when the effect begins to diminish.

This is why our usual protocol moves from the initial three-session course to much less frequent treatment, generally every 6 to 12 months when needed.

What Is Recovery Like After Mesotherapy?

Most patients have relatively little downtime.

Immediately after treatment, temporary:

• small injection marks,
• redness,
• swelling,
• tenderness,
• or minor bruising

may occur.

Small raised areas may occasionally be visible at individual injection sites for a short period.

Under-eye swelling can be more noticeable because of the anatomy of this region.

What Should I Avoid After Mesotherapy?

Immediately after treatment, unnecessary rubbing and pressure should be avoided.

Patients may also be advised to temporarily avoid:

• strenuous exercise,
• sauna and excessive heat,
• aggressive facial treatments,
• and potentially irritating skin products.

Sun protection is particularly important following skin procedures.

Advice varies slightly according to the product and area treated.

What Are the Risks of Mesotherapy?

Mesotherapy is minimally invasive, but that does not mean it is risk-free.

Common temporary effects include redness, swelling, bruising and injection-site tenderness.

Less commonly, patients may develop:

• prolonged swelling,
• infection,
• nodules,
• prolonged inflammatory reactions,
• or an unwanted response to a particular product.

The under-eye region requires particular caution because of its vascular and lymphatic anatomy.

Phosphatidylcholine treatment beneath the chin has a different side-effect profile from facial skin mesotherapy and can produce considerably more local swelling.

Who May Not Be Suitable for Mesotherapy?

Treatment may need to be postponed or avoided in patients with:

• active infection in the treatment area,
• open wounds,
• certain uncontrolled skin conditions,
• known significant allergy to an ingredient,
• or medical circumstances that make elective injections inappropriate.

Medication and relevant medical history should be reviewed before treatment.

Elective aesthetic injection treatments are generally postponed during pregnancy and breastfeeding.

Mesotherapy vs PRP

They are not the same treatment.

PRP, or platelet-rich plasma, is prepared from the patient’s own blood.

Mesotherapy typically involves manufactured formulations containing substances such as hyaluronic acid, amino acids or polynucleotides.

They may both be used with regenerative intentions but have completely different biological compositions.

Mesotherapy vs Exosome Treatment

These are also different.

Exosomes are extracellular vesicles released by cells and are involved in biological signalling.

They are not the same as hyaluronic acid, amino acids or polynucleotide formulations used for mesotherapy.

At Anka Plastic Surgery, exosome treatment is considered a separate regenerative treatment protocol.

Mesotherapy vs Skin Boosters

“Skin booster” is a broad commercial and clinical term often used for injectable treatments designed to improve skin hydration and quality.

Some hyaluronic acid skin boosters overlap conceptually with mesotherapy.

However, not all mesotherapy products are skin boosters, and products marketed as skin boosters do not all contain the same ingredients.

For this reason, we prefer to focus on what the product contains and what it is intended to achieve, rather than the label alone.

Mesotherapy vs Dermal Fillers

Dermal fillers are mainly designed to restore or create structural volume.

They may be used for the lips, cheeks, chin, jawline and other facial contouring indications.

Mesotherapy is generally directed towards skin quality rather than facial architecture.

A patient with significant midface volume loss, for example, may require filler or fat grafting rather than repeated mesotherapy.

Likewise, a patient with significant skin laxity may need an energy-based or surgical lifting procedure.

Can Mesotherapy Replace Surgery?

No.

Mesotherapy can support skin quality, but it cannot remove substantial excess skin or reposition descended facial tissues.

It should not be presented as an alternative to blepharoplasty, facelift or neck lift when the anatomical problem requires surgery.

Similarly, phosphatidylcholine injections may be useful for a small submental fat deposit, but they do not replace liposuction when the amount of fat is substantial.

Our Approach to Mesotherapy at Anka Plastic Surgery

We consider mesotherapy an ingredient-based treatment rather than one standard injection protocol.

Treatment is selected according to the tissue and the problem being treated.

For general facial skin quality, amino acid and hyaluronic acid formulations may be used.

For the under-eye area, we select products specifically suited to that anatomy.

For patients interested in regenerative skin treatment, polynucleotide formulations can be considered.

For small, localised deposits of submental fat, phosphatidylcholine mesotherapy may occasionally be used as a separate treatment protocol.

Our usual skin-treatment schedule begins with three sessions approximately two weeks apart, followed by maintenance approximately every 6 to 12 months according to individual need.

The objective is not to inject the greatest number of products or create artificial facial volume.

The aim is to select the appropriate biological content for the appropriate tissue and use it conservatively.

Mesotherapy in Turkey for International Patients

International patients considering mesotherapy in Istanbul can begin with an online preliminary assessment.

Clear photographs may help identify whether the main concern is:

• skin quality,
• under-eye hollowing,
• fine lines,
• facial volume loss,
• or submental fat.

This distinction is important because a patient asking for mesotherapy may actually be better suited to another treatment.

Final product selection and injection planning are therefore performed after direct examination.

Conclusion

Mesotherapy is not one product and does not have one universal purpose.

Hyaluronic acid and amino acid combinations may be used to support skin hydration and quality.

Under-eye formulations are selected specifically for the delicate lower eyelid region.

Polynucleotides, often referred to as “salmon DNA” treatments, are used for regenerative skin support.

In a completely different application, phosphatidylcholine mesotherapy may be considered for small localised deposits of fat beneath the chin.

At Anka Plastic Surgery, the key principle is to choose treatment according to anatomy and ingredient rather than using the same mesotherapy cocktail for every patient.